Side effects from corticosteroid therapy can vary whether you've used corticosteroids short term or long term. Side effects from short-term corticosteroid use include insomnia, agitation, euphoria, increased appetite. More side effects are from long-term use than from short, and they include weight gain, ulcers, hypertension, hyperglycemia, edema and more. If you plan to stop using cortiocsteroids, you must taper your use. Get instructions from your doctor on exactly how to do this. If you stop using them suddenly, you risk getting acute adrenal insufficiency syndrome, which can be fatal.

